This is a demonstrator that show differents works achieved during the FOCUS project.
An important feature of the brachytherapy procedure proposed within the FOCUS project is the real-time dynamic dosimetry re-planning capability through a feedback loop linking prostate perception and the advanced treatment planning system. This requires the capability to detect seeds within the pros...
New brachytherapy treatment planning system was developed using 3D-Slicer as front-end software. The proposed MC-PRISM (MonteCarlo based Prostate bRachytherapy plannIng System) was wrapped into 3D-Slicer. MC-PRISM allows fast Monte Carlo (MC) simulation with local or distant calculation on server. T...
In brachytherapy, plans are routinely calculated using the AAPM TG43 formalism which considers the patient as a simple water object. An accurate modeling of the physical processes considering patient heterogeneity using Monte Carlo simulation (MCS) methods is currently too time-consuming and computationally demanding to be routinely used. In this work we developped a fast and accurate MCS using GPU architecture, new variance reducation technique and accurate phase-space source modeling. The proposed method is capable of simulate a complete patient dosimetry in less than 1 s.
Prostate volume changes due to edema occurrence during transperineal permanent brachytherapy should be taken under consideration to ensure optimal dose delivery. Available edema models, based on prostate volume observations, face several limitations. Therefore, patient-specific models need to be developed to accurately account for the impact of edema. In this project we present a biomechanical model developed to reproduce edema resolution patterns documented in the literature. Using the biphasic mixture theory and finite element analysis, the proposed model takes into consideration the mechanical properties of the pubic area tissues in the evolution of prostate edema.